Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Replicative aging is associated with loss of genetic heterogeneity from extrachromosomal circular DNA in Saccharomyces cerevisiae.

Nucleic acids research - 20 Aug 2020

Prada-Luengo Iñigo, Møller Henrik D, Henriksen Rasmus A, Gao Qian, Larsen Camilla Eggert, Alizadeh Sefa, Maretty Lasse, Houseley Jonathan, Regenberg Birgitte

Abstract excerpt

Circular DNA can arise from all parts of eukaryotic chromosomes. In yeast, circular ribosomal DNA (rDNA) accumulates dramatically as cells age, however little is known about the accumulation of other chromosome-derived circles or the contribution of such circles to genetic variation in aged cells. We profiled circular DNA in Saccharomyces cerevisiae populations sampled when young and after extensive aging. Young...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular Senescence
Share to DNA, Circular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Replication

Share to Inheritance Patterns

Share to Monosaccharide Transport Proteins

Share to Repetitive Sequences, Nucleic Acid

Share to Replication Origin

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 32609810
DOI: 10.1093/nar/gkaa545
PMCID: PMC7430651

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Replicative aging is associated with loss of genetic heterogeneity from extrachromosomal circular DNA in Saccharomyces cerevisiae.PMID 32609810Read ↗

The adaptive potential of circular DNA accumulation in ageing cells.Semantic proximity Read ↗

Extrachromosomal circular DNA is common in yeast.Semantic proximity Read ↗

Genomic copy-number loss is rescued by self-limiting production of DNA circlesSemantic proximity Read ↗

Replicating and cycling stores of information perpetuate lifeSemantic proximity Read ↗

Beyond the Linear Genome: Comprehensive Determination of the Endogenous Circular Elements in <i>C. elegans</i> and Human Genomes via an Unbiased Genomic-Biophysical MethodSemantic proximity Read ↗

Multi-generational silencing dynamics control cell agingSemantic proximity Read ↗

Diversity of genome organisation.Semantic proximity Read ↗

Multigenerational silencing dynamics control cell agingSemantic proximity Read ↗

R-loops and regulatory changes in chronologically ageing fission yeast cells drive non-random patterns of genome rearrangements.Semantic proximity Read ↗

Cell enlargement drives aging-associated proteome remodeling and shortens replicative lifespanSemantic proximity Read ↗

R-loops and regulatory changes in chronologically ageing fission yeast cells drive non-random patterns of genome rearrangementsSemantic proximity Read ↗

Reproductive potential and instability of the rDNA region of the Saccharomyces cerevisiae yeast: Common or separate mechanisms of regulation?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.