Synthetic expansion of non-coding DNA reveals physiological constraints on genome size

Abstract excerpt

Genome size varies widely across eukaryotes, largely because of differences in non-coding DNA, but the physiological consequences of this variation remain unclear. To directly test how non-coding DNA abundance influences cellular physiology, we engineered a scalable genome-expansion system in the budding yeast S. cerevisiae that increases genome size while leaving the endogenous genome unchanged. By sequentially...

Topics

Open a Topic to create a Post that cites this publication.

• Biological Evolution
• Evolution, Molecular
• Genome
• Genome Size
• Models, Genetic
• Mutation
• Mutation Rate
• Selection, Genetic

Identifiers and source

Literature Corpus work

43884410-a049-515e-9aa2-e7e526f2f68e

DOI

10.64898/2026.06.26.734810