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Article

Dosage compensation can buffer copy-number variation in wild yeast.

eLife - 8 May 2015

Hose James, Yong Chris Mun, Sardi Maria, Wang Zhishi, Newton Michael A, Gasch Audrey P

Abstract excerpt

Aneuploidy is linked to myriad diseases but also facilitates organismal evolution. It remains unclear how cells overcome the deleterious effects of aneuploidy until new phenotypes evolve. Although laboratory strains are extremely sensitive to aneuploidy, we show here that aneuploidy is common in wild yeast isolates, which show lower-than-expected expression at many amplified genes. We generated diploid strain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25955966
DOI: 10.7554/eLife.05462
PMCID: PMC4448642

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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