immuneSIM: tunable multi-feature simulation of B- and T-cell receptor repertoires for immunoinformatics benchmarking

Abstract excerpt

<h4>Summary</h4> B- and T-cell receptor repertoires of the adaptive immune system have become a key target for diagnostics and therapeutics research. Consequently, there is a rapidly growing number of bioinformatics tools for immune repertoire analysis. Benchmarking of such tools is crucial for ensuring reproducible and generalizable computational analyses. Currently, however, it remains challenging to create sta...

Topics

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• Algorithms
• Base Sequence
• CD4-Positive T-Lymphocytes
• CD8-Positive T-Lymphocytes
• Gene Rearrangement, T-Lymphocyte
• Receptors, Antigen, T-Cell
• Sequence Analysis, RNA
• V(D)J Recombination

Identifiers and source

Literature Corpus work

1f81e757-79b5-5fa1-842f-ac14667d28de

DOI

10.1101/759795