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Article

Role of Lipids in the Pathogenesis of Parkinson's Disease.

International journal of molecular sciences - 16 Aug 2024

Kamano Shumpei, Ozawa Daisaku, Ikenaka Kensuke, Nagai Yoshitaka

Abstract excerpt

Aggregation of α-synuclein (αSyn) and its accumulation as Lewy bodies play a central role in the pathogenesis of Parkinson's disease (PD). However, the mechanism by which αSyn aggregates in the brain remains unclear. Biochemical studies have demonstrated that αSyn interacts with lipids, and these interactions affect the aggregation process of αSyn. Furthermore, genetic studies have identified mutations in lipid...

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Identifiers

PMID: 39201619
DOI: 10.3390/ijms25168935
PMCID: PMC11354291

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