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Article

Sphingolipid changes in Parkinson L444P GBA mutation fibroblasts promote α-synuclein aggregation.

Brain : a journal of neurology - 29 Apr 2022

Galvagnion Céline, Marlet Frederik Ravnkilde, Cerri Silvia, Schapira Anthony H V, Blandini Fabio, Di Monte Donato A

Abstract excerpt

Intraneuronal accumulation of aggregated α-synuclein is a pathological hallmark of Parkinson's disease. Therefore, mechanisms capable of promoting α-synuclein deposition bear important pathogenetic implications. Mutations of the glucocerebrosidase 1 (GBA) gene represent a prevalent Parkinson's disease risk factor. They are associated with loss of activity of a key enzyme involved in lipid metabolism,...

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Identifiers

PMID: 35362022
DOI: 10.1093/brain/awab371
PMCID: PMC9050548

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