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Article

Altered ceramide metabolism is a feature in the extracellular vesicle-mediated spread of alpha-synuclein in Lewy body disorders.

Acta neuropathologica - 1 Dec 2021

Kurzawa-Akanbi Marzena, Tammireddy Seshu, Fabrik Ivo, Gliaudelytė Lina, Doherty Mary K, Heap Rachel, Matečko-Burmann Irena, Burmann Björn M, Trost Matthias, Lucocq John M, Gherman Anda V, Fairfoul Graham, Singh Preeti, Burté Florence, Green Alison, McKeith Ian G, Härtlova Anetta, Whitfield Phillip D, Morris Christopher M

Abstract excerpt

Mutations in glucocerebrosidase (GBA) are the most prevalent genetic risk factor for Lewy body disorders (LBD)-collectively Parkinson's disease, Parkinson's disease dementia and dementia with Lewy bodies. Despite this genetic association, it remains unclear how GBA mutations increase susceptibility to develop LBD. We investigated relationships between LBD-specific glucocerebrosidase deficits, GBA-related...

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Identifiers

PMID: 34514546
DOI: 10.1007/s00401-021-02367-3
PMCID: PMC8568874

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