Article

Hexosylceramides are elevated in human, mouse and cellular Parkinson's disease and cause gene upregulations in neurons mimicking responses to pathogens

2025-08-01

Abstract excerpt

<title>Abstract</title> <p>The pathology of Parkinson's Disease (PD) arises from a deposits of oligomeric forms of alpha-synuclein (gene: SNCA, aSyn). Glycosphingolipids facilitate the formation of such oligomers and interfere with their lysosomal degradation. Consequently, mutations in genes involved in glycosphingolipid transport and degradation enhance the risk and severity of PD. In particular, mutations and...

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Literature Corpus work: e250a87e-a170-5470-89b4-449db607e52f
DOI: 10.21203/rs.3.rs-6633816/v1

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