Article

Shared and Distinct Lipid Profiles in amygdala from Sporadic and GBA-associated Parkinson’s Diseases

2024-10-12

Abstract excerpt

Parkinson’s Disease (PD) is a neurodegenerative disorder characterised by the deposition of protein-lipid inclusions, containing alpha-synuclein, neuronal cell loss and disruptions in lipid metabolism such as those associated with GBA mutations. GBA mutations are together an important genetic risk factor for PD and are associated with a decrease in glucocerebrosidase, a lysosomal glycoprotein encoded by GBA , i...

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Literature Corpus work: 7973e7b6-e58c-5c05-9ca7-3848edd8a3b7
DOI: 10.1101/2024.10.11.617800

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