Article

High resolution long-read telomere sequencing reveals dynamic mechanisms in aging and cancer

2023-11-29

Abstract excerpt

Telomeres are the protective nucleoprotein structures at the end of linear eukaryotic chromosomes. Telomeres’ repetitive nature and length have traditionally challenged the precise assessment of the composition and length of individual human telomeres. Here, we present Telo-seq to resolve bulk, chromosome arm-specific and allele-specific human telomere lengths using Oxford Nanopore Technologies’ native long-read s...

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Literature Corpus work: cc6098f6-2cb5-50be-95c8-49e00354e22f
DOI: 10.1101/2023.11.28.569082

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