Article

Single-molecule architecture and heterogeneity of human telomeric DNA and chromatin

2022-05-09

Abstract excerpt

Telomeres are essential for linear genomes, yet their repetitive DNA content and somatic variability has hindered attempts to delineate their chromatin architectures. We performed single-molecule chromatin fiber sequencing (Fiber-seq) on human cells with a fully resolved genome, enabling nucleotide-precise maps of the genetic and chromatin structure of all telomeres. Telomere fibers are predominantly comprised of...

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Literature Corpus work: 58fa61ce-50f2-5251-86d8-6430f7019d81
DOI: 10.1101/2022.05.09.491186

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