Article

Digital telomere measurement by long-read sequencing distinguishes healthy aging from disease

2023-12-01

Abstract excerpt

Telomere length is an important biomarker of organismal aging and cellular replicative potential, but existing measurement methods are limited in resolution and accuracy. Here, we deploy digital telomere measurement by nanopore sequencing to understand how distributions of human telomere length change with age and disease. We measure telomere attrition and de novo elongation with unprecedented resolution in genet...

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Literature Corpus work: 50dfd43a-5b25-5641-b77f-5c333ca59213
DOI: 10.1101/2023.11.29.569263

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