Article

Characterization of telomere variant repeats using long reads enables allele-specific telomere length estimation

2023-11-30

Abstract excerpt

Telomeres are regions of repetitive DNA at the ends of linear chromosomes which protect chromosome ends from degradation. Telomere lengths have been extensively studied in the context of aging and disease, though most studies use average telomere lengths which are of limited utility. We present a method for identifying all 92 telomere alleles from long read sequencing data. Individual telomeres are identified usin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7fe80264-0c9d-5048-acc1-b8910c410af2
DOI: 10.21203/rs.3.rs-3673861/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Characterization of telomere variant repeats using long reads enables allele-specific telomere length estimationDOI 10.21203/rs.3.rs-3673861/v1Read

Characterization of telomere variant repeats using long reads enables allele-specific telomere length estimation.Semantic proximity Read

Telomere variant sequences encode the genetic blueprint for allele-specific telomere lengthSemantic proximity Read

High resolution long-read telomere sequencing reveals dynamic mechanisms in aging and cancerSemantic proximity Read

High resolution long-read telomere sequencing reveals dynamic mechanisms in aging and cancer.Semantic proximity Read

Telogator: a method for reporting chromosome-specific telomere lengths from long readsSemantic proximity Read

Single-molecule variation in telomeric sequence and structure across humansSemantic proximity Read

Telomere extension by telomerase and ALT generates variant repeats by mechanistically distinct processes.Semantic proximity Read

Computel: Computation of Mean Telomere Length from Whole-Genome Next-Generation Sequencing DataSemantic proximity Read

High-throughput telomere length measurement at nucleotide resolution using the PacBio high fidelity sequencing platformSemantic proximity Read

Multidimensional telomere diversity and inheritance at individual and population scalesSemantic proximity Read

Nanopore whole-genome sequencing reveals conserved chromosome-specific telomere architecture across tissues and populationsSemantic proximity Read

Haplotype Diversity and Sequence Heterogeneity of Human TelomeresSemantic proximity Read