Article

Telomere variant sequences encode the genetic blueprint for allele-specific telomere length

2026-08-10

Abstract excerpt

The ends of human chromosomes are capped by specialized nucleoprotein structures known as telomeres, which are essential for genome stability. Recent advances in long-read sequencing have enabled allele-specific telomere length measurements at nucleotide resolution, uncovering extreme heterogeneity in telomere length between alleles that is determined at birth and gradually shortens with age. However, the mechanis...

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Literature Corpus work: 329e648a-1f09-502f-a66f-249c50fed988
DOI: 10.64898/2026.08.04.741677

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