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Digital telomere measurement by long-read sequencing distinguishes healthy aging from disease

18 Jun 2024

Abstract excerpt

Telomere length is an important biomarker of organismal aging and cellular replicative potential, but existing measurement methods are limited in resolution and accuracy. Here, we deploy digital telomere measurement (DTM) by nanopore sequencing to understand how distributions of human telomere length change with age and disease. We measure telomere attrition and de novo elongation with up to 30 bp resolution in...

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Share to Telomeres, Telomerase, and Senescence

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 38890274
DOI: 10.1038/s41467-024-49007-4

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