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Article

High resolution long-read telomere sequencing reveals dynamic mechanisms in aging and cancer.

Nature communications - 18 Jun 2024

Schmidt Tobias T, Tyer Carly, Rughani Preeyesh, Haggblom Candy, Jones Jeffrey R, Dai Xiaoguang, Frazer Kelly A, Gage Fred H, Juul Sissel, Hickey Scott, Karlseder Jan

Abstract excerpt

Telomeres are the protective nucleoprotein structures at the end of linear eukaryotic chromosomes. Telomeres' repetitive nature and length have traditionally challenged the precise assessment of the composition and length of individual human telomeres. Here, we present Telo-seq to resolve bulk, chromosome arm-specific and allele-specific human telomere lengths using Oxford Nanopore Technologies' native long-read...

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Identifiers

PMID: 38890299
DOI: 10.1038/s41467-024-48917-7
PMCID: PMC11189484

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