Article

FibrilPaints for visualisation and ubiquitination of Huntingtin amyloid fibrils

2025-12-22

Abstract excerpt

Huntington’s disease (HD) is caused by expansion of a polyglutamine tract in the huntingtin (Htt) protein, leading to aggregation of the exon 1 fragment (HttEx1) into amyloid fibrils. HttEx1 forms one of the lowest-complexity amyloid cores known, its fibril core consists of a single amino acid, glutamine. With emerging therapies improving patients’ prospects by silencing expression of HTT, tools to monitor HttEx1...

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Literature Corpus work: cc59a87d-eeda-52e2-971f-ab2f411815c7
DOI: 10.64898/2025.12.19.695423

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