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Article

Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease.

Human molecular genetics - 1 Jan 2010

Sathasivam Kirupa, Lane Amin, Legleiter Justin, Warley Alice, Woodman Ben, Finkbeiner Steve, Paganetti Paolo, Muchowski Paul J, Wilson Stuart, Bates Gillian P

Abstract excerpt

Huntington's disease (HD) is a late-onset neurodegenerative disorder that is characterized neuropathologically by the presence of neuropil aggregates and nuclear inclusions. However, the profile of aggregate structures that are present in the brains of HD patients or of HD mouse models and the re...

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Identifiers

PMID: 19825844
DOI: 10.1093/hmg/ddp467
PMCID: PMC2792149

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AFM
SDS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19825844-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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