Article

Structural and functional landscape of α-synuclein fibril conformations amplified from cerebrospinal fluid

2022-07-13

Abstract excerpt

Lewy body dementias are pathologically defined by the deposition of α-synuclein fibrils into inclusions throughout the brain. Cerebrospinal fluid(CSF) in disease harbors circulating α-synuclein-fibril seeds, and parental α-synuclein fibrils can template core structure into amplified fibrils. Using cryo-electron microscopy, we identify six novel α-synuclein fibril assemblies amplified from ten CSF samples (3.8Å to...

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Literature Corpus work: 51a8ee33-9297-5444-944f-3fb0f5c18ffa
DOI: 10.1101/2022.07.13.499896

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