Article

Integrative determination of the atomic structure of mutant huntingtin exon 1 fibrils implicated in Huntington’s disease

2023-07-21

Abstract excerpt

Neurodegeneration in Huntington’s disease (HD) is accompanied by the aggregation of fragments of the mutant huntingtin protein, a biomarker of disease progression. A particular pathogenic role has been attributed to the aggregation-prone huntingtin exon 1 (HTTex1), generated by aberrant splicing or proteolysis, and containing the expanded polyglutamine (polyQ) segment. Unlike amyloid fibrils from Parkinson’s and A...

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Literature Corpus work: 34b28f2a-e006-5fad-92db-17cd55560eb7
DOI: 10.1101/2023.07.21.549993

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