Article

Probing How Anti-Huntingtin Antibodies Bind the Fibrillar Fuzzy Coat Using Solid-State NMR

2025-04-27

Abstract excerpt

Antibodies are critical for the immune response and serve as important tools due to their ability to recognize specific amino acid sequences, or epitopes. Based on the latter, they are utilized as diagnostic tools in biological and biomedical research. Huntington’s disease (HD) is a neurodegenerative condition caused by CAG repeat expansions in the huntingtin (HTT) gene and characterized by amyloid-like protein de...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5d695e23-53f7-5fb0-9b8e-1e54d441ac44
DOI: 10.1101/2025.04.25.650083

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Probing How Anti-Huntingtin Antibodies Bind the Fibrillar Fuzzy Coat Using Solid-State NMRDOI 10.1101/2025.04.25.650083Read

Aducanumab Binding to Aβ1-42 Fibrils Alters Dynamics of the N-Terminal Tail While Preserving the Fibril CoreSemantic proximity Read

Integrative determination of the atomic structure of mutant huntingtin exon 1 fibrils implicated in Huntington’s diseaseSemantic proximity Read

Fibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine core.Semantic proximity Read

Integrative determination of atomic structure of mutant huntingtin exon 1 fibrils implicated in Huntington disease.Semantic proximity Read

Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment.Semantic proximity Read

FibrilPaints for visualisation and ubiquitination of Huntingtin amyloid fibrilsSemantic proximity Read

Conformational studies of pathogenic expanded polyglutamine protein deposits from Huntington’s diseaseSemantic proximity Read

Macrocyclic Peptide Tools for Huntingtin-bound HAP40Semantic proximity Read

Highly Potent Peptide Therapeutics To Prevent Protein Aggregation In Huntington’s DiseaseSemantic proximity Read

High-Affinity, Structure-Validated and Selective Macrocyclic Peptide Tools for Chemical Biology Studies of HuntingtinSemantic proximity Read

Protofilament Structure and Supramolecular Polymorphism of Aggregated Mutant Huntingtin Exon 1.Semantic proximity Read

Amyloid fibril polymorphism: a challenge for molecular imaging and therapySemantic proximity Read