Article

Structural and functional landscape of α-synuclein fibril conformations amplified from cerebrospinal fluid

2022-07-22

Abstract excerpt

<title>Abstract</title> <p>Lewy body dementias are pathologically defined by the deposition of α-synuclein fibrils into inclusions throughout the brain. Cerebrospinal fluid(CSF) in disease harbors circulating α-synuclein-fibril seeds, and parental α-synuclein fibrils can template core structure into amplified fibrils. Using cryo-electron microscopy, we identify six novel α-synuclein fibril assemblies amplified fr...

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Literature Corpus work: 1b52d7a8-8559-5126-9b23-0a4aad68563c
DOI: 10.21203/rs.3.rs-1832778/v1

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