Article

Functional consequences of genetic risk for neuropsychiatric conditions at chr22q

2025-07-07

Abstract excerpt

Understanding how common and rare genetic variation raises risk for neuropsychiatric disease remains a major challenge. We identify the long arm of chromosome 22 (chr22q) as a region where common polygenic risk for schizophrenia, autism, ADHD, and lower IQ is associated with coordinated downregulation of gene expression in postmortem human brain tissue. The effects are strikingly consistent between neuropsychiatri...

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Literature Corpus work: c19e9de0-ce8a-5557-8484-cd8d333e9a6e
DOI: 10.1101/2025.07.01.25330642

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