Article
Identification of epistatic mutations and insights into the evolution of the influenza virus using a mass-based protein phylogenetic approach.
Molecular phylogenetics and evolution - 1 Apr 2018
Akand Elma H, Downard Kevin M
Abstract excerpt
A mass-based protein phylogenetic approach developed in this laboratory has been applied to study mutation trends and identify consecutive or near-consecutive mutations typically associated with positive epistasis. While epistasis is thought to occur commonly during the evolution of viruses, the extent of epistasis in influenza, and its role in the evolution of immune escape and drug resistant mutants, remains to...
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