Article

Lgr5-mediated restraint of β-catenin is essential for B-lymphopoiesis and leukemia-initiation

2020-03-13

Abstract excerpt

Upon productive immunoglobulin gene rearrangement, expression of a functional pre-B cell receptor (pre-BCR) initiates positive selection of pre-B cells, clonal expansion and self-renewal 1-2 . Studying mechanisms driving this first wave of B-lymphopoiesis, we identified the G-protein coupled receptor Lgr5 as an essential initiator of positive selection. Lgr5 was extensively studied as determinant of stem cell pop...

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Literature Corpus work: cbf301d6-ec40-58c8-8e67-3fe903f21a26
DOI: 10.1101/2020.03.12.989277

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