Article

Dynamic phosphatase-recruitment controls B-cell selection and oncogenic signaling

2023-03-15

Abstract excerpt

Initiation of B-cell receptor (BCR) 1 signaling, and subsequent antigen-encounter in germinal centers 2,3 represent milestones of B-lymphocyte development that are both marked by sharp increases of CD25 surface-expression. Oncogenic signaling in B-cell leukemia (B-ALL) 4 and lymphoma 5 also induced CD25-surface expression. While CD25 is known as an IL2-receptor chain on T- and NK-cells 6–9 , the significance...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 946afcef-3145-539a-8f81-7c3c273383b3
DOI: 10.1101/2023.03.13.532151

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dynamic phosphatase-recruitment controls B-cell selection and oncogenic signalingDOI 10.1101/2023.03.13.532151Read

PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis.Semantic proximity Read

Rewiring of B cell receptor signaling by Epstein–Barr virus LMP2ASemantic proximity Read

Lgr5-mediated restraint of β-catenin is essential for B-lymphopoiesis and leukemia-initiationSemantic proximity Read

In Vivo Roles of CDC25 Phosphatases: Biological Insight into the Anti-Cancer Therapeutic TargetsSemantic proximity Read

Protein Kinase Cδ Promotes Transitional B Cell-Negative Selection and Limits Proximal B Cell Receptor Signaling To Enforce ToleranceSemantic proximity Read

Wiskott-Aldrich Syndrome Interacting Protein Deficiency Uncovers the Role of the Co-receptor CD19 as a Generic Hub for PI3 Kinase Signaling in B CellsSemantic proximity Read

Rack1 regulates B-cell development and function by binding to and stabilizing the transcription factor Pax5Semantic proximity Read

Signalome-wide mapping of the NFκB pathway in T-cells reveals novel targets for immunotherapySemantic proximity Read

The role of PTEN as a PI(3,4)P2 lipid phosphatase in Class I phosphoinositide 3-kinase signallingSemantic proximity Read

Dysregulation of PAX5 causes uncommitted B cell development and tumorigenesis in miceSemantic proximity Read

Phostensin Enables Lymphocyte Integrin Activation and Population of Peripheral Lymphoid OrgansSemantic proximity Read

Butyrophilin 2A2 promotes T cell immunoregulation by enhancing CD45 phosphatase activity within the immune synapseSemantic proximity Read