Article

Pre-TCR-Targeted Immunotherapy for T-cell Acute Lymphoblastic Leukemia

2024-06-02

Abstract excerpt

<h4>SUMMARY</h4> Targeted immunotherapy for T-cell acute lymphoblastic leukemia (T-ALL), an aggressive tumor of developing T-cell progenitors, is an urgent unmet need, especially for relapsed/refractory (r/r) disease. Selective T-ALL targeting is challenging due to the shared antigen expression between leukemic and normal T cells. Here we identify the pre-TCR, a surface receptor essential for T-cell development,...

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Literature Corpus work: bbbcf130-f83c-5ebd-8e14-3706b603f50b
DOI: 10.1101/2024.05.29.596375

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