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Article

Revisiting β-Catenin Signaling in T-Cell Development and T-Cell Acute Lymphoblastic Leukemia.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Feb 2020

Bigas Anna, Guillén Yolanda, Schoch Leonie, Arambilet David

Abstract excerpt

β-Catenin/CTNNB1 is critical for leukemia initiation or the stem cell capacity of several hematological malignancies. This review focuses on a general evaluation of β-catenin function in normal T-cell development and T-cell acute lymphoblastic leukemia (T-ALL). The integration of the existing literature offers a state-of-the-art dissection of the complexity of β-catenin function in leukemia initiation and...

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PMID: 31854474
DOI: 10.1002/bies.201900099

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