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Article

Targeting the B-cell receptor signaling pathway in B lymphoid malignancies

8 May 2014

Abstract excerpt

PURPOSE OF REVIEW: Normal B cells that have failed to productively rearrange immunoglobulin V region genes encoding a functional B-cell receptor (BCR) are destined to die. Likewise, the majority of B-cell malignancies remain dependent on functional BCR signaling, whereas in some subtypes BCR expression is missing and, apparently, counterselected. Here, we summarize the recent experimental evidence for the...

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Share to Acute Lymphoblastic Leukemia research
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PMID: 24811161
DOI: 10.1097/moh.0000000000000048

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