Article

Targeted engagement of β-catenin-Ikaros complexes in refractory B-cell malignancies

2023-03-15

Abstract excerpt

<h4>ABSTRACT</h4> In most cell types, nuclear β-catenin functions as prominent oncogenic driver and pairs with TCF7-family factors for transcriptional activation of MYC. Surprisingly, B-lymphoid malignancies not only lacked expression and activating lesions of β-catenin but critically depended on GSK3β for effective β-catenin degradation. Our interactome studies in B-lymphoid tumors revealed that β-catenin forme...

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Literature Corpus work: 1a0ea6d3-2ceb-580b-8752-1a1f799858ce
DOI: 10.1101/2023.03.13.532152

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