Article

Nucleus confinement within concave microcavities modulates nuclear morphology, subnuclear dynamics and mechanotransduction in human osteosarcoma cells

2026-03-23

Abstract excerpt

Cells dynamically integrate biochemical and mechanical signals arising from their surrounding microenvironment to regulate morphology and behavior. Mechanical cues like matrix stiffness, surface topography, and other physical perturbations modify biophysical signals. Surface topography, particularly curvature regime acts as any important mediator of mechanotransduction by coordinating cytoskeletal organization, fo...

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Literature Corpus work: cbe8601c-a266-5759-b070-cfa952691e00
DOI: 10.64898/2026.03.20.712604

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