Article

Substrate Curvature Influences Cytoskeletal Rearrangement and Modulates Macrophage Phenotype

2024-08-12

Abstract excerpt

Inflammation serves as a critical defense mechanism against pathogens and tissue damage but can lead to chronic diseases, such as cardiovascular disease and diabetes, when dysregulated. Macrophages play a pivotal role in orchestrating inflammatory responses, transitioning from pro-inflammatory M1 to anti-inflammatory M2 phenotypes to resolve inflammation and promote tissue repair. Current approaches to modulate ma...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e2339a70-cfdc-500b-b207-b1ca1bdad99f
DOI: 10.1101/2024.08.12.607593

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Substrate Curvature Influences Cytoskeletal Rearrangement and Modulates Macrophage PhenotypeDOI 10.1101/2024.08.12.607593Read

Substrate curvature influences cytoskeletal rearrangement and modulates macrophage phenotype.Semantic proximity Read

Micro- and Nanopatterned Topographical Cues for Regulating Macrophage Cell Shape and Phenotype.Semantic proximity Read

Biophysical regulation of macrophages in health and diseaseSemantic proximity Read

Biomaterial-based physical regulation of macrophage behaviour.Semantic proximity Read

Novel 3-D macrophage spheroid model reveals reciprocal regulation of immunomechanical stress and mechano-immunological responseSemantic proximity Read

Cell geometry dictates TNFα-induced genome responseSemantic proximity Read

Shear Stress Induces a Time-Dependent Inflammatory Response in Human Monocyte-Derived MacrophagesSemantic proximity Read

Cytoskeletal prestress: The cellular hallmark in mechanobiology and mechanomedicineSemantic proximity Read

Micropatterning transcriptionally and phenotypically reprograms endothelial cells.Semantic proximity Read

Steps in Mechanotransduction Pathways that Control Cell MorphologySemantic proximity Read

Macrophage Mechano-Responsiveness Within Three-Dimensional Tissue Matrix upon Mechanotherapy-Associated Strains.Semantic proximity Read

Microgroove substrates unveil topography-driven, dynamic 3D nuclear deformationsSemantic proximity Read