Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disease‐specific phenotypes in dopamine neurons from human iPS‐based models of genetic and sporadic Parkinson's disease

8 Mar 2012

Abstract excerpt

Induced pluripotent stem cells (iPSC) offer an unprecedented opportunity to model human disease in relevant cell types, but it is unclear whether they could successfully model age-related diseases such as Parkinson's disease (PD). Here, we generated iPSC lines from seven patients with idiopathic PD (ID-PD), four patients with familial PD associated to the G2019S mutation in the Leucine-Rich Repeat Kinase 2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to Parkinson's Disease Mechanisms and Treatments
Share to Pluripotent Stem Cells Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22407749
DOI: 10.1002/emmm.201200215

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disease‐specific phenotypes in dopamine neurons from human iPS‐based models of genetic and sporadic Parkinson's diseasePMID 22407749Read ↗

Induced pluripotent stem cell (iPSC)-derived dopaminergic models of Parkinson's diseaseSemantic proximity Read ↗

Age-related pathological impairments in induced neurons derived from patients with idiopathic Parkinson’s diseaseSemantic proximity Read ↗

Diverging Parkinson’s Disease Pathology between patient-derived <i> GBA <sup>N370S</sup> , LRRK2 <sup>G2019S</sup> </i> and engineered <i> SNCA <sup>A53T</sup> </i> iPSC-derived Dopaminergic NeuronsSemantic proximity Read ↗

Modeling Parkinson’s Disease Using Induced Pluripotent Stem CellsSemantic proximity Read ↗

iPS models of Parkin and PINK1.Semantic proximity Read ↗

Organoid and pluripotent stem cells in Parkinson’s disease modeling: an expert view on their value to drug discoverySemantic proximity Read ↗

Mitochondrial Phenotypes in Parkinson's Diseases-A Focus on Human iPSC-Derived Dopaminergic Neurons.Semantic proximity Read ↗

Dopamine and cortical iPSC-derived neurons with different Parkinsonian mutations show variation in lysosomal and mitochondrial dysfunction: implications for protein deposition versus selective cell lossSemantic proximity Read ↗

Autophagy Dysfunction in iPSCs-Derived Neurons and Midbrain Organoids Carrying a <i>SNCA</i> TriplicationSemantic proximity Read ↗

Parallel Neurodegenerative Phenotypes in Sporadic Parkinson’s Disease Fibroblasts and Midbrain Dopamine NeuronsSemantic proximity Read ↗

Modeling Cell-Cell Interactions in Parkinson’s Disease Using Human Stem Cell-Based ModelsSemantic proximity Read ↗

Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.