Article

NOL10 is required for NUP98-DDX10 leukemia

2024-02-07

Abstract excerpt

<title>Abstract</title> <p>NUP98 rearrangements associated with acute myeloid leukemia and myelodysplastic syndromes generate NUP98-fusion proteins. One such fusion protein, NUP98-DDX10, contains the putative RNA helicase DDX10. The molecular mechanism by which NUP98-DDX10 induces leukemia is not well understood. Here, we show that 24 amino acids within the DDX10 moiety of NUP98-DDX10 are crucial for cell immorta...

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Literature Corpus work: cbb3a68f-6e48-5891-98f6-39ad99e1a1ba
DOI: 10.21203/rs.3.rs-3896248/v1

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