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NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights

26 Sept 2011

Abstract excerpt

Structural chromosomal rearrangements of the Nucleoporin 98 gene (NUP98), primarily balanced translocations and inversions, are associated with a wide array of hematopoietic malignancies. NUP98 is known to be fused to at least 28 different partner genes in patients with hematopoietic malignancies, including acute myeloid leukemia, chronic myeloid leukemia in blast crisis, myelodysplastic syndrome, acute...

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PMID: 21948299
DOI: 10.1182/blood-2011-07-328880

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