Article

NUP98::NSD1 and FLT3-ITD collaborate to generate acute myeloid leukemia

2022-12-08

Abstract excerpt

<title>Abstract</title> <p>Nucleoporin 98 (NUP98) fusion genes and FMS-related tyrosine kinase 3 gene (FLT3) internal tandem duplications (ITDs) are recurrent events in patients with acute myeloid leukemia (AML). The NUP98::NSD1 fusion, which joins the amino terminal portion of NUP98 to the carboxy terminal portion of NSD1 (Nuclear receptor-binding SET Domain 1) is the most common NUP98 fusion in human AML. AML p...

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Literature Corpus work: 07318da1-e5da-50fa-8c1f-f6b9a7f24381
DOI: 10.21203/rs.3.rs-2347569/v1

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