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Article

DDX41: exploring the roles of a versatile helicase.

Biochemical Society transactions - 28 Feb 2024

Winstone Lacey, Jung Yohan, Wu Yuliang

Abstract excerpt

DDX41 is a DEAD-box helicase and is conserved across species. Mutations in DDX41 have been associated with myeloid neoplasms, including myelodysplastic syndrome and acute myeloid leukemia. Though its pathogenesis is not completely known, DDX41 has been shown to have many cellular roles, including in pre-mRNA splicing, innate immune sensing, ribosome biogenesis, translational regulation, and R-loop metabolism. In...

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Identifiers

PMID: 38348889
DOI: 10.1042/BST20230725
PMCID: PMC10903454

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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