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NUP98 oncofusions in myeloid malignancies: An update on molecular mechanisms and therapeutic opportunities

1 Sept 2024

Abstract excerpt

Abstract Acute myeloid leukemia (AML) is an aggressive hematological malignancy with a heterogeneous molecular landscape. In the pediatric context, the NUP98 gene is a frequent target of chromosomal rearrangements that are linked to poor prognosis and unfavorable treatment outcomes in different AML subtypes. The translocations fuse NUP98 to a diverse array of partner genes, resulting in fusion proteins with novel...

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PMID: 39323480
DOI: 10.1002/hem3.70013

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