Article

Fusion oncoproteins and cooperating mutations define disease phenotypes in<i>NUP98</i>-rearranged leukemia

2025-01-22

Abstract excerpt

Leukemias with NUP98 rearrangements exhibit heterogeneous phenotypes correlated to fusion partners, whereas the mechanism responsible for this heterogeneity is poorly understood. Through genome-wide mutational and transcriptional analyses of 177 NUP98 -rearranged leukemias, we show that cooperating alterations are associated with differentiation status even among leukemias sharing the same NUP98 fusions, such as N...

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Literature Corpus work: b74b44a7-dd75-54c8-b253-6f88f838eedc
DOI: 10.1101/2025.01.21.25320683

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