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Article

Delineating domains and functions of NUP98 contributing to the leukemogenic activity of NUP98-HOX fusions.

Leukemia research - 1 Apr 2011

Yung Eric, Sekulovic Sanja, Argiropoulos Bob, Lai Courteney K, Leung Malina, Berg Tobias, Vollett Sarah, Chang Vicky Chi-Dan, Wan Adrian, Wong Sandy, Humphries R Keith

Abstract excerpt

To determine the contribution of the common N-terminal truncation of NUP98 in NUP98-translocations resulting in acute myeloid leukemia, we have conducted a structure-function analysis of NUP98 in the context of NUP98-HOXA10HD, a novel, canonical NUP98-Hox fusion that significantly enhances the self-renewal capacity of hematopoietic stem cells and collaborates with Meis1 to induce AML in our mouse models. Our...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21130494
DOI: 10.1016/j.leukres.2010.10.006
PMCID: PMC4072657

Genes

NUP98

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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