Article

5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages

2017-07-12

Abstract excerpt

5-Hydroxymethylcytosine (5hmC) is an important mammalian DNA epigenetic modification that has been linked to gene regulation and cancer pathogenesis. Here we explored the diagnostic potential of 5hmC in circulating cell-free DNA (cfDNA) using a sensitive chemical labeling-based low-input shotgun sequencing approach. We sequenced cell-free 5hmC from 49 patients of seven different cancer types and found distinct fea...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 941c6b06-781d-5dbe-9a76-b4917bd1721d
DOI: 10.1101/162081

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stagesDOI 10.1101/162081Read

DNA 5-Hydroxymethylcytosines from Cell-free Circulating DNA as Diagnostic Biomarkers for Human CancersSemantic proximity Read

Towards precision medicine: advances in 5‐hydroxymethylcytosine cancer biomarker discovery in liquid biopsySemantic proximity Read

5-Hydroxymethylome in Circulating Cell-Free DNA as A Potential Biomarker for Non-Small-Cell Lung CancerSemantic proximity Read

Global DNA methylomes reveal oncogenic-associated 5-hydroxylmethylated cytosine (5hmC) signatures in the cell-free DNA of cancer patientsSemantic proximity Read

5-hydroxymethylcytosine Profilings in Circulating Cell-free DNA as diagnostic biomarkers for DLBCLSemantic proximity Read

5-Hydroxymethylcytosines from Circulating Cell-free DNA as Diagnostic and Prognostic Markers for Hepatocellular CarcinomaSemantic proximity Read

Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNASemantic proximity Read

5‐Hydroxymethylcytosine signature in circulating cell‐free DNA as a potential diagnostic factor for early‐stage colorectal cancer and precancerous adenomaSemantic proximity Read

5-Hydroxymethylcytosine (5hmC) at or near cancer mutation hot spots as potential targets for early cancer detection.Semantic proximity Read

Epigenetic modifications of cfDNA in liquid biopsy for the cancer care continuumSemantic proximity Read

5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations.Semantic proximity Read

Methylation in cell-free DNA for early cancer detectionSemantic proximity Read