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Crystal structure of <i>E. coli</i> Nissle 1917 flagellin reveals novel features that modulate bacterial motility but not TLR5 recognition

2026-03-30

Abstract excerpt

The probiotic E. coli Nissle 1917 (EcN) strain is known to promote intestinal homeostasis via flagellin, the protomer of its motility apparatus, the flagellum. The flagellin of EcN shows atypical features, namely a hypervariable region (HVR), whose structure and significance have remained elusive. We therefore determined the crystal structure of the E. coli Nissle 1917 flagellin FliC at a resolution of 1.2 Å whi...

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Literature Corpus work
cb9655a3-d9a1-5cfe-bbcc-c17ce6095fad
DOI
10.64898/2026.03.27.714778
Open publication

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Crystal structure of <i>E. coli</i> Nissle 1917 flagellin reveals novel features that modulate bacterial motility but not TLR5 recognitionDOI 10.64898/2026.03.27.714778
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