Article
Adaptation of adherent-invasive E. coli to gut environment: Impact on flagellum expression and bacterial colonization ability.
Gut microbes - 3 May 2020
Sevrin Gwladys, Massier Sébastien, Chassaing Benoit, Agus Allison, Delmas Julien, Denizot Jérémy, Billard Elisabeth, Barnich Nicolas
Abstract excerpt
The pathogenesis of Crohn's disease (CD) is multifactorial and involves genetic susceptibility, environmental triggers and intestinal microbiota. Adherent-invasive Escherichia coli (AIEC) are flagellated bacteria more prevalent in CD patients than in healthy subjects and promote chronic intestinal inflammation. We aim at deciphering the role of flagella and flagellin modulation by intestinal conditions. AIEC...
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