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Distinctive Recognition of Flagellin by Human and Mouse Toll-Like Receptor 5

8 Jul 2016

Abstract excerpt

Toll-like receptor 5 (TLR5) is a receptor of the innate immune system that recognizes flagellin from certain bacterial species and triggers an inflammatory response. The Salmonella dublin flagellin in complex with zebrafish TLR5 has been crystallized previously. In the present study, we extrapolate the structure of this complex using structure-guided mutagenesis to determine the recognition modes of human and...

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PMID: 27391968
DOI: 10.1371/journal.pone.0158894

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