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Article

A conserved TLR5 binding and activation hot spot on flagellin.

Scientific reports - 20 Jan 2017

Song Wan Seok, Jeon Ye Ji, Namgung Byeol, Hong Minsun, Yoon Sung-Il

Abstract excerpt

Flagellin is a bacterial protein that polymerizes into the flagellar filament and is essential for bacterial motility. When flagellated bacteria invade the host, flagellin is recognized by Toll-like receptor 5 (TLR5) as a pathogen invasion signal and eventually evokes the innate immune response. Here, we provide a conserved structural mechanism by which flagellins from Gram-negative γ-proteobacteria and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28106112
DOI: 10.1038/srep40878
PMCID: PMC5247705

Genes

TLR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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