CD4⁺-T-Cell Responses Generated during Murine<i>Salmonella enterica</i>Serovar Typhimurium Infection Are Directed towards Multiple Epitopes within the Natural Antigen FliC

Abstract excerpt

The flagellar filament protein FliC is a natural antigen recognized by memory CD4+ T cells recovered from Salmonella enterica serovar Typhimurium-infected humans and mice. To further investigate T-cell responses to FliC, we derived FliC-specific CD4+-T-cell clones from mice of two different haplotypes following oral S. enterica serovar Typhimurium infection. Using C-terminal truncations of MalE-FliC recombinant...

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