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Article

The Role of Flagellin B in Vibrio anguillarum-Induced Intestinal Immunity and Functional Domain Identification.

Frontiers in immunology - 1 Jan 2021

Gao Quanxin, Yi Shaokui, Li Yang, Luo Jinping, Xing Qianqian, Yang Xia, Zhao Ming, Min Minghua, Wang Qian, Wang Yabing, Ma Lingbo, Peng Shiming

Abstract excerpt

Vibrio anguillarum, an opportunistic pathogen of aquatic animals, moves using a filament comprised of polymerised flagellin proteins. Flagellins are essential virulence factors for V. anguillarum infection. Herein, we investigated the effects of flagellins (flaA, flaB, flaC, flaD and flaE) on cell apoptosis, TLR5 expression, and production of IL-8 and TNF-α. FlaB exhibited the strongest immunostimulation effects....

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Identifiers

PMID: 34912344
DOI: 10.3389/fimmu.2021.774233
PMCID: PMC8667730

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