Article

The Histone Methyltransferase SETD2 Modulates Oxidative Stress to Attenuate Colonic Inflammation and Tumorigenesis in Mice

2020-07-14

Abstract excerpt

<h4>BACKGROUND & AIMS</h4> Inflammatory bowel disease (IBD) is a complex and relapsing inflammatory disease, and patients with IBD exhibit a higher risk of developing colorectal cancer (CRC). Epithelial barrier disruption is one of the major causes of IBD in which epigenetic modulation is pivotal. However, the epigenetic mechanisms underlying the epithelial barrier integrity regulation remain largely unexplored....

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Literature Corpus work: cb889fb6-0f0b-5849-8830-571548914a9a
DOI: 10.1101/2020.07.13.201624

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