Article

Integrating Inflammatory and Epigenetic Signatures in IBD-Associated Colorectal Carcinogenesis: Models, Mechanisms, and Clinical Implications

2025-08-26

Abstract excerpt

The rising global prevalence of inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, is paralleled by an increased risk of colitis-associated colorectal cancer (CAC). Persistent intestinal inflammation promotes genetic instability and epigenetic reprogramming within epithelial and immune cells, driving the multistep transition from inflammation to neoplasia. This review integrates f...

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Literature Corpus work: 5846d32e-27a6-5fb4-b513-44d8ed000ee5
DOI: 10.20944/preprints202508.1820.v1

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