Article

SETD2 Deficiency Promotes Inflammatory Bowel Disease via Oxidative Stress and FasL-induced Apoptosis

2022-11-12

Abstract excerpt

SET-domain-containing 2 (SETD2) is known as the major trimethyltransferase that regulates the methylation of histone H3 lysine 36 (H3K36), which has been found frequently mutated in IBD samples. Although SETD2 deficiency has been proven to modulate oxidative stress, the specific mechanisms of SETD2 in IBD are still little known. To investigate the possible role of SETD2 in IBD, we generated and genotyped epitheliu...

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Literature Corpus work: 877a51b1-09ce-5822-b104-692589943242
DOI: 10.1101/2022.11.10.516012

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